Jacalin is a lectin which reacts with D-galactose. We have tested jacalin on 75 samples of different formalin- and alcohol-fixed tissues. A consistent cytoplasmic stain of the histiocytes was observed in paraffin-embedded tissues in all cases studied of reactive sinus histiocytosis, macrophages in clear centres of follicular hyperplasia, in tuberculosis granulomas and in osteoclast-like giant cells in a breast carcinoma, We failed to find any clear binding of jacalin to the cells of eosinophilic granulomas, giant cell tumors of tendon sheath, pleomorphic malignant fibrous histiocytomas, Hodgkin's disease, melanomas, nevi or signet ring cell carcinomas of the breast and stomach. It seems that jacalin is a good marker for free histiocytes/macrophages, not for fixed histiocytes and tumors related to them. This lectin might play a role in differential diagnosis with histiocyte mimicking processes.
机构:
Mayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USAMayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USA
Hoyer, James D.
Grogg, Karen L.
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Mayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USAMayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USA
Grogg, Karen L.
Hanson, Curds A.
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Mayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USAMayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USA
Hanson, Curds A.
Gamez, Jeffrey D.
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Mayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USAMayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USA
Gamez, Jeffrey D.
Dogan, Ahmet
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Mayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USAMayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Rochester, MN 55905 USA
机构:Secçào Autónoma de Biotecnologia, Laboratório de Genética Molecular, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Quinta da Torre, 2825 Monte de Caparica, Lisboa
SANTOS, AC
OSORIOALMEIDA, L
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机构:Secçào Autónoma de Biotecnologia, Laboratório de Genética Molecular, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Quinta da Torre, 2825 Monte de Caparica, Lisboa
机构:
FAC MED MARSEILLE, UNITE RICKETTSIES, 27 BLVD JEAN MOULIN, F-13385 MARSEILLE 5, FRANCEFAC MED MARSEILLE, UNITE RICKETTSIES, 27 BLVD JEAN MOULIN, F-13385 MARSEILLE 5, FRANCE
STEIN, A
RAOULT, D
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FAC MED MARSEILLE, UNITE RICKETTSIES, 27 BLVD JEAN MOULIN, F-13385 MARSEILLE 5, FRANCEFAC MED MARSEILLE, UNITE RICKETTSIES, 27 BLVD JEAN MOULIN, F-13385 MARSEILLE 5, FRANCE