REACTIVE SPECIES AND THEIR ACCUMULATION ON RADICAL-DAMAGED PROTEINS

被引：215

作者：

DEAN, RT ^{[1
]}

GIESEG, S ^{[1
]}

DAVIES, MJ ^{[1
]}

机构：

[1] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 11期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

D O I：

10.1016/0968-0004(93)90145-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydroperoxides and catechols are described as novel reactive products of radical attack on proteins. These species, like other components of oxidized and otherwise damaged proteins, may accumulate in some biological systems. We propose that the reactive species may then attack other biomolecules, and constitute both a marker and a mechanism of age-related pathologies.

引用

页码：437 / 441

页数：5

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[3]

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