SYNTHESIS OF FLUORINATED ANALOGS OF LIPID-A

被引：8

作者：

VYPLEL, H

SCHOLZ, D

LOIBNER, H

KERN, M

BEDNARIK, K

SCHALLER, H

机构：

[1] Sandoz Forschungsinstitut, A-1235 Wien

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 10期

关键词：

LIPID-X; LIPID-A; FLUORINATION; ENZYMATIC SYNTHESIS; FLUORINATED DISACCHARIDES;

D O I：

10.1016/S0040-4039(00)91596-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In order to study structure-activity relationships of lipid A derivatives, a series of fluorinated analogues of lipid X was synthesized. Subsequently, these were converted enzymatically into the corresponding disaccharidic lipid A analogues using lipid A synthase. This further demonstrates the low substrate specificity of this enzyme.

引用

页码：1261 / 1264

页数：4

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