CLINICAL EFFECTS AND INVITRO STUDIES OF TRIFLUOROTHYMIDINE COMBINED WITH INTERFERON-ALPHA FOR TREATMENT OF DRUG-RESISTANT AND DRUG-SENSITIVE HERPES-SIMPLEX VIRUS-INFECTIONS

被引:50
作者
BIRCH, CJ [1 ]
TYSSEN, DP [1 ]
TACHEDJIAN, G [1 ]
DOHERTY, R [1 ]
HAYES, K [1 ]
MIJCH, A [1 ]
LUCAS, CR [1 ]
机构
[1] FAIRFIELD HOSP,DIV MED,FAIRFIELD,VIC,AUSTRALIA
关键词
D O I
10.1093/infdis/166.1.108
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Three AIDS patients with severe cutaneous herpes simplex virus (HSV) infection refractory to therapy with acyclovir and foscarnet (2 patients) were treated with a topical preparation of trifluorothymidine (TFT) and interferon-alpha. Complete healing of lesions occurred in 1 patient; a second had significant regression of the infected area. In the third, the lesion was stabilized twice after application of the preparation and reduced in size after a subsequent treatment. In vitro studies confirmed that isolates from these patients were acyclovir- or acyclovir/foscarnet-resistant. In addition, they revealed strong synergy between TFT and interferon-alpha for these isolates and for strains with wild-type drug sensitivity profiles. Topical TFT/interferon-alpha may be of benefit in the therapy of mucocutaneous HSV infections, especially when they are resistant to treatment with systemic antiviral agents.
引用
收藏
页码:108 / 112
页数:5
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