METHOXY AND HYDROXY DERIVATIVES OF 3,4-DIHYDRO-3-(DI-NORMAL-PROPYLAMINO)-2H-1-BENZOPYRANS - NEW SYNTHESIS AND DOPAMINERGIC ACTIVITY

被引：16

作者：

ALNEIRABEYEH, M

REYNAUD, D

PODONA, T

OU, L

PERDICAKIS, C

COUDERT, G

GUILLAUMET, G

PICHAT, L

GHARIB, A

SARDA, N

机构：

[1] UNIV ORLEANS,CHIM BIOORGAN & ANALYT LAB,CNRS,URA 499,BP 6759,F-45067 ORLEANS 2,FRANCE

[2] INST NATL SCI APPL,INSERM,4205,CHIM BIOL LAB,F-69621 VILLEURBANNE,FRANCE

[3] CENS,F-91191 GIF SUR YVETTE,FRANCE

[4] FAC PHARM NANCY,CHIM ORGAN LAB,F-54000 NANCY,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 05期

关键词：

3,4-DIHYDRO-3-AMINO-2H-1-BENZOPYRANS; RACEMIC SYNTHESIS AND RESOLUTION; DOPAMINERGIC RECEPTORS; BRAIN; RAT;

D O I：

10.1016/0223-5234(91)90145-D

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of methoxy and hydroxy derivatives of 3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran from readily available or commercial omicron-hydroxybenzaldehydes is described in six steps. The enantiomers of 8-hydroxy-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran 1b have been resolved. It is shown that the compound (-)-1b is a more selective D-2 agonist, compared to apomorphine.

引用

收藏

页码：497 / 504

页数：8

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