THE DESIGN OF A NOVEL CLASS OF POTASSIUM CHANNEL ACTIVATING DRUGS, 2-(2,2-DIMETHYLBENZOPYRAN-4-YL)-PYRIDINE-1-OXIDES

被引：24
作者：
ATTWOOD, MR
JONES, PS
KAY, PB
PACIOREK, PM
REDSHAW, S
机构：
[1] Roche Products Limited, Welwyn Garden City
来源：
LIFE SCIENCES | 1991年 / 48卷 / 08期
关键词：
D O I：
10.1016/0024-3205(91)90096-T
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The features of cromakalim responsible for its potassium channel activating property were investigated. A hypothesis relating three-dimensional structure to binding to a putative receptor was developed and used successfully to design the potent and structurally novel agents, 2-(2,2-dimethylbenzopyran-4-yl)-pyridine-1-oxides.
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收藏
页码：803 / 810
页数：8
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