THE DESIGN OF A NOVEL CLASS OF POTASSIUM CHANNEL ACTIVATING DRUGS, 2-(2,2-DIMETHYLBENZOPYRAN-4-YL)-PYRIDINE-1-OXIDES

被引：24

作者：

ATTWOOD, MR

JONES, PS

KAY, PB

PACIOREK, PM

REDSHAW, S

机构：

[1] Roche Products Limited, Welwyn Garden City

来源：

LIFE SCIENCES | 1991年 / 48卷 / 08期

关键词：

D O I：

10.1016/0024-3205(91)90096-T

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The features of cromakalim responsible for its potassium channel activating property were investigated. A hypothesis relating three-dimensional structure to binding to a putative receptor was developed and used successfully to design the potent and structurally novel agents, 2-(2,2-dimethylbenzopyran-4-yl)-pyridine-1-oxides.

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页码：803 / 810

页数：8

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