INHIBITION OF HUMAN DIHYDROFOLATE-REDUCTASE BY ANTIFOLYL POLYGLUTAMATES

被引：16

作者：

KUMAR, P

KISLIUK, RL

GAUMONT, Y

FREISHEIM, JH

NAIR, MG

机构：

[1] TUFTS UNIV,DEPT BIOCHEM,HLTH SCI CAMPUS,BOSTON,MA 02111

[2] MED COLL OHIO,DEPT BIOCHEM,TOLEDO,OH 43699

[3] UNIV S ALABAMA,DEPT BIOCHEM,MOBILE,AL 36688

来源：

BIOCHEMICAL PHARMACOLOGY | 1989年 / 38卷 / 03期

关键词：

D O I：

10.1016/0006-2952(89)90397-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：541 / 543

页数：3

共 17 条

[1]

ALLEGRA CJ, 1987, J BIOL CHEM, V262, P13520

[2]

BLAKLEY RL, 1969, BIOCH FOLIC ACID REL, P93

[3] SYNTHESIS AND ANTIFOLATE ACTIVITY OF 10-DEAZAMINOPTERIN [J].

DEGRAW, JI ;

KISLIUK, RL ;

GAUMONT, Y ;

BAUGH, CM ;

NAIR, MG .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (05) :552-553

[4] SYNTHESIS AND ANTI-TUMOR ACTIVITY OF 10-ALKYL-10-DEAZAMINOPTERINS - A CONVENIENT SYNTHESIS OF 10-DEAZAMINOPTERIN [J].

DEGRAW, JI ;

BROWN, VH ;

TAGAWA, H ;

KISLIUK, RL ;

GAUMONT, Y ;

SIROTNAK, FM .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (10) :1227-1230

[5] PURIFICATION AND CHARACTERIZATION OF DIHYDROFOLATE-REDUCTASE FROM METHOTREXATE-RESISTANT HUMAN-LYMPHOBLASTOID CELLS [J].

DELCAMP, TJ ;

SUSTEN, SS ;

BLANKENSHIP, DT ;

FREISHEIM, JH .

BIOCHEMISTRY, 1983, 22 (03) :633-639

[6]

FRIEDKIN M, 1962, FED PROC, V21, P176

[7]

GALIVAN J, 1980, MOL PHARMACOL, V17, P105

[8] INTRACELLULAR PHARMACOKINETICS OF METHOTREXATE POLYGLUTAMATES IN HUMAN-BREAST CANCER-CELLS - SELECTIVE RETENTION AND LESS DISSOCIABLE BINDING OF 4-NH2-10-CH3-PTEROYLGLUTAMATE4 AND 4-NH2-10-CH3-PTEROYLGLUTAMATE5 TO DIHYDROFOLATE-REDUCTASE [J].

JOLIVET, J ;

CHABNER, BA .

JOURNAL OF CLINICAL INVESTIGATION, 1983, 72 (03) :773-778

[9]

KISLIUK RL, 1984, FOLATE ANTAGONISTS T, V1, P1

[10]

KISLIUK RL, 1985, 2ND P WORKSH FOL ANT, P319

← 1 2 →