Activity Of Aggregation Properties Of Neutrophils In Patients With Arterial Hypertension With Type 2 Diabetes Mellitus

Preservation of a large number of pathologies in the population of industrially developed countries is accompanied by a wide prevalence of arterial hypertension and type 2 diabetes. This condition is very dangerous high frequency of occurrence of thromboses. It was revealed that in the basis of this, the excessive aggregation of the formed elements of the blood often lies. The aim is to assess the aggregation potential of neutrophils in patients with arterial hypertension with type 2 diabetes mellitus. We examined 42 patients of the second adult age (mean age 49.3 +/- 2.9 years) with arterial hypertension of 1-2 degree with diabetes mellitus type 2. The control group consisted of 26 clinically healthy people of the same age. All examined persons gave written informed consent to participate in the study. Biochemical, hematological and statistical methods of investigation were used. The high frequency of thrombosis of various localizations in hypertension in type 2 diabetes is closely related to the development of neutrophil hyperagregulation. Weakening of antioxidant protection of plasma with activation of processes of lipid peroxidation in it, are an important basis of this disturbance. This process often occurs in conditions of a combination of arterial hypertension with diabetes mellitus type 2. It was found that in persons with arterial hypertension and type 2 diabetes mellitus an obvious weakening of neutrophil disaggregation is observed. As a result, patients receive a sharply increased risk of thrombosis of any location, which can lead to disability and death.