STRUCTURE OF SIMIAN VIRUS-40 AT 3.8-A RESOLUTION

被引：575
作者：
LIDDINGTON, RC
YAN, Y
MOULAI, J
SAHLI, R
BENJAMIN, TL
HARRISON, SC
机构：
[1] HARVARD UNIV,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02138
[2] HARVARD UNIV,DEPT BIOCHEM & MOLEC BIOL,CAMBRIDGE,MA 02138
[3] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
来源：
NATURE | 1991年 / 354卷 / 6351期
关键词：
D O I：
10.1038/354278a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The crystallographically determined structure of simian virus 40 shows that the 72 pentamers of viral protein VP1, which form the outer shell, have identical conformations except for the C-terminal arms of their subunits. Five arms emerge from each pentamer and insert into neighbouring pentamers. This tying together of standard building blocks allows for the required variability in packing geometry without sacrificing specificity.
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页码：278 / 284
页数：7
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