CHLORPROMAZINE AND PROTRIPTYLINE PHOTO-TOXICITY - PHOTOSENSITIZED, OXYGEN INDEPENDENT RED-CELL HEMOLYSIS

被引：80
作者：
KOCHEVAR, IE
LAMOLA, AA
机构：
[1] BELL TEL LABS INC,MURRAY HILL,NJ 07974
[2] COLUMBIA UNIV BARNARD COLL,DEPT BIOCHEM,NEW YORK,NY 10027
[3] COLUMBIA UNIV BARNARD COLL,DEPT DERMATOL,NEW YORK,NY 10027
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1979年 / 29卷 / 04期
关键词：
D O I：
10.1111/j.1751-1097.1979.tb07768.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Abstract—Red blood cell lysis photosensitized by chlorpromazine and protriptyline was investigated. Oxygen independent sensitized photohemolysis was observed with both compounds. When chlorpromazine and protriptyline were irradiated in the absence of red cells, both formed photoproducts which lysed red cells. These results indicate that chlorpromazine and protriptyline represent a new mechanistic class of phototoxic compounds which photosensitize membrane disruption by oxygen independent processes. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：791 / 796
页数：6
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