TYROSINE-HYDROXYLASE GENE-EXPRESSION IN HUMAN VENTRAL MESENCEPHALON - DETECTION OF TYROSINE-HYDROXYLASE MESSENGER-RNA IN NEURITES

被引：24
|
作者：
DUMAS, S
JAVOYAGID, F
HIRSCH, E
AGID, Y
MALLET, J
机构：
[1] CNRS,NEUROBIOL CELLULAIRE LAB,F-91198 GIF SUR YVETTE,FRANCE
[2] HOP LA PITIE SALPETRIERE,MED EXPTL LAB,INSERM,U289,F-75651 PARIS 13,FRANCE
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 1990年 / 25卷 / 04期
关键词：
dendrites; Parkinson's disease; TH;
D O I：
10.1002/jnr.490250415
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The distribution of both tyrosine hydroxylase (TH) antigen and messenger RNA was investigated in the ventral mesencephalon from human brain using a 35S‐labeled human TH cDNA probe and a polyclonal TH antibody. A hybridization signal was detected not only in the perikaryon but also in the neurites, most probably dendrites, of immunoreactive neurons. In cell bodies, the level of TH mRNA varies, revealing a regional heterogeneity. In the substantia nigra of patients with Parkinson's disease the number of labeled cells was markedly reduced as compared to controls. Copyright © 1990 Wiley‐Liss, Inc.
引用
收藏
页码：569 / 575
页数：7
相关论文
共 50 条
  • [41] REGULATION OF TYROSINE-HYDROXYLASE GENE-EXPRESSION IN THE RAT CAROTID-BODY BY HYPOXIA
    CZYZYKKRZESKA, MF
    BAYLISS, DA
    LAWSON, EE
    MILLHORN, DE
    JOURNAL OF NEUROCHEMISTRY, 1992, 58 (04) : 1538 - 1546
  • [42] EFFECT OF EXERCISE AND AGE ON TYROSINE-HYDROXYLASE GENE-EXPRESSION IN THE ADRENAL-MEDULLA
    TUMER, N
    HALE, C
    LAWLER, J
    LOWENTHAL, D
    STRONG, R
    FASEB JOURNAL, 1991, 5 (06): : A1734 - A1734
  • [43] TYROSINE-HYDROXYLASE AND METHIONINE-ENKEPHALIN IN THE HUMAN MESENCEPHALON - IMMUNOCYTOCHEMICAL LOCALIZATION AND RELATIONSHIPS
    GASPAR, P
    BERGER, B
    GAY, M
    HAMON, M
    CESSELIN, F
    VIGNY, A
    JAVOYAGID, F
    AGID, Y
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 1983, 58 (02) : 247 - 267
  • [44] NEONATAL STRESS - EFFECTS OF HYPOGLYCEMIA AND HYPOXIA ON ADRENAL TYROSINE-HYDROXYLASE GENE-EXPRESSION
    DECRISTOFARO, JD
    LAGAMMA, EF
    PEDIATRIC RESEARCH, 1994, 36 (06) : 719 - 723
  • [45] STRUCTURE OF THE HUMAN TYROSINE-HYDROXYLASE GENE - ALTERNATIVE SPLICING FROM A SINGLE GENE ACCOUNTS FOR GENERATION OF 4 MESSENGER-RNA TYPES
    KOBAYASHI, K
    KANEDA, N
    ICHINOSE, H
    KISHI, F
    NAKAZAWA, A
    KUROSAWA, Y
    FUJITA, K
    NAGATSU, T
    JOURNAL OF BIOCHEMISTRY, 1988, 103 (06): : 907 - 912
  • [46] NORMALIZATION OF TYROSINE-HYDROXYLASE ACTIVITY IN-VIVO IN THE STRIATUM OF TRANSGENIC MICE CARRYING HUMAN TYROSINE-HYDROXYLASE GENE - A MICRODIALYSIS STUDY
    NAKAHARA, D
    HASHIGUTI, H
    KANEDA, N
    SASAOKA, T
    NAGATSU, T
    NEUROSCIENCE LETTERS, 1993, 158 (01) : 44 - 46
  • [47] SUPPRESSED TYROSINE-HYDROXYLASE GENE-EXPRESSION IN THE TUBEROINFUNDIBULAR DOPAMINERGIC SYSTEM DURING LACTATION
    WANG, HJ
    HOFFMAN, GE
    SMITH, MS
    ENDOCRINOLOGY, 1993, 133 (04) : 1657 - 1663
  • [48] REGULATION OF TYROSINE-HYDROXYLASE GENE-EXPRESSION DURING DIFFERENTIATION OF NEUROBLASTOMA-CELLS
    SUMMERHILL, EM
    WOOD, K
    FISHMAN, MC
    MOLECULAR BRAIN RESEARCH, 1987, 2 (02): : 99 - 103
  • [49] MULTIPLE MESSENGER-RNAS OF MONKEY TYROSINE-HYDROXYLASE
    ICHIKAWA, S
    ICHINOSE, H
    NAGATSU, T
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (03) : 1331 - 1336
  • [50] INVITRO SYNTHESIS OF TYROSINE-HYDROXYLASE
    MALLET, J
    PRIVAT, A
    SAMOLYK, D
    BEROD, A
    KELLER, A
    PUJOL, JF
    COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES, 1981, 292 (06): : 155 - +
12345