TYROSINE-HYDROXYLASE GENE-EXPRESSION IN HUMAN VENTRAL MESENCEPHALON - DETECTION OF TYROSINE-HYDROXYLASE MESSENGER-RNA IN NEURITES

被引：24
|
作者：
DUMAS, S
JAVOYAGID, F
HIRSCH, E
AGID, Y
MALLET, J
机构：
[1] CNRS,NEUROBIOL CELLULAIRE LAB,F-91198 GIF SUR YVETTE,FRANCE
[2] HOP LA PITIE SALPETRIERE,MED EXPTL LAB,INSERM,U289,F-75651 PARIS 13,FRANCE
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 1990年 / 25卷 / 04期
关键词：
dendrites; Parkinson's disease; TH;
D O I：
10.1002/jnr.490250415
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The distribution of both tyrosine hydroxylase (TH) antigen and messenger RNA was investigated in the ventral mesencephalon from human brain using a 35S‐labeled human TH cDNA probe and a polyclonal TH antibody. A hybridization signal was detected not only in the perikaryon but also in the neurites, most probably dendrites, of immunoreactive neurons. In cell bodies, the level of TH mRNA varies, revealing a regional heterogeneity. In the substantia nigra of patients with Parkinson's disease the number of labeled cells was markedly reduced as compared to controls. Copyright © 1990 Wiley‐Liss, Inc.
引用
收藏
页码：569 / 575
页数：7
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