MITOMYCIN-C - SMALL, FAST AND DEADLY (BUT VERY SELECTIVE)

被引：463

作者：

TOMASZ, M

机构：

来源：

CHEMISTRY & BIOLOGY | 1995年 / 2卷 / 09期

关键词：

D O I：

10.1016/1074-5521(95)90120-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitomycin C, an important antitumor drug and antibiotic, has an extraordinary ability to crosslink DNA with high efficiency and absolute specificity for the sequence CpG. Recent results have shown how mitomycin C crosslinks DNA, and why the sequence specificity is so complete, This new understanding may allow the design of agents that mimic mitomycin C's economy of structure and can crosslink other sequences.

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页码：575 / 579

页数：5

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