ANTIVIRAL ACTIVITY OF S-7HNA ON THE INFECTIVITY AND REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1 IN CULTURED-CELLS

被引：3
作者：
MURATORE, O
SCHITO, AP
TONOLI, EL
MOSTI, L
机构：
[1] Institute of Microbiology, University of Genoa, Genova, I-16132, Viale Benedetto XV
[2] Institute of Pharmaceutical Sciences, University of Genoa, Genova, I-16132, Viale Benedetto XV
来源：
JOURNAL OF CHEMOTHERAPY | 1995年 / 7卷 / 01期
关键词：
S-7HNA; ANTIVIRAL DRUGS; HERPES SIMPLEX VIRUSES; HSV-1; INFECTIVITY;
D O I：
10.1179/joc.1995.7.1.30
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effect of sodium salt of the acid related to ester S-7 (i.e. S-7HNa) on the infectivity and replication of herpes simplex virus type 1 in Vero cultured cells was studied. S-7HNa, at the highest concentration lacking cytotoxicity (10 mM), produced, at various inocula, a 70% inhibition of HSV-1 infectivity with respect to the plaque formation detected in control infected cultures. This inhibitory activity was substantiated by studies on progeny production, S-7HNa revealed a therapeutic index higher than that of the correlative ester (S-7).
引用
收藏
页码：30 / 32
页数：3
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