ANTIVIRAL ACTIVITY OF S-7HNA ON THE INFECTIVITY AND REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1 IN CULTURED-CELLS

被引：3
|
作者：
MURATORE, O
SCHITO, AP
TONOLI, EL
MOSTI, L
机构：
[1] Institute of Microbiology, University of Genoa, Genova, I-16132, Viale Benedetto XV
[2] Institute of Pharmaceutical Sciences, University of Genoa, Genova, I-16132, Viale Benedetto XV
来源：
JOURNAL OF CHEMOTHERAPY | 1995年 / 7卷 / 01期
关键词：
S-7HNA; ANTIVIRAL DRUGS; HERPES SIMPLEX VIRUSES; HSV-1; INFECTIVITY;
D O I：
10.1179/joc.1995.7.1.30
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effect of sodium salt of the acid related to ester S-7 (i.e. S-7HNa) on the infectivity and replication of herpes simplex virus type 1 in Vero cultured cells was studied. S-7HNa, at the highest concentration lacking cytotoxicity (10 mM), produced, at various inocula, a 70% inhibition of HSV-1 infectivity with respect to the plaque formation detected in control infected cultures. This inhibitory activity was substantiated by studies on progeny production, S-7HNa revealed a therapeutic index higher than that of the correlative ester (S-7).
引用
收藏
页码：30 / 32
页数：3
相关论文
共 50 条
  • [1] Antiviral activity of FA-11H on the infectivity and replication of herpes simplex virus type 1 in cultured cells
    Muratore, O
    Schito, AP
    Tonoli, EL
    Gianoglio, S
    Mosti, L
    MICROBIOLOGICA, 1998, 21 (03): : 275 - 279
  • [2] In vitro antiviral activity of dermaseptins against herpes simplex virus type-1
    Belaid, A
    Aouni, M
    Khelifa, R
    Trabelsi, A
    Jemmali, M
    Hani, K
    JOURNAL OF MEDICAL VIROLOGY, 2002, 66 (02) : 229 - 234
  • [3] TROMANTADINE INHIBITS A LATE STEP IN HERPES-SIMPLEX VIRUS TYPE-1 REPLICATION AND SYNCYTIUM FORMATION
    ICKES, DE
    VENETTA, TM
    PHONPHOK, Y
    ROSENTHAL, KS
    ANTIVIRAL RESEARCH, 1990, 14 (02) : 75 - 85
  • [4] THE HERPES-SIMPLEX VIRUS TYPE-1 PARTICLE - STRUCTURE AND MOLECULAR FUNCTIONS
    HAARR, L
    SKULSTAD, S
    APMIS, 1994, 102 (05) : 321 - 346
  • [5] THE REPLICATING INTERMEDIATES OF HERPES-SIMPLEX VIRUS TYPE-1 DNA ARE RELATIVELY SHORT
    DESHMANE, SL
    RAENGSAKULRACH, B
    BERSON, JF
    FRASER, NW
    JOURNAL OF NEUROVIROLOGY, 1995, 1 (02) : 165 - 176
  • [6] Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1
    Jiang, Kai
    Feng, Jing
    Qi, Xia
    Ran, Lili
    Xie, Lixin
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2022, 16 : 4311 - 4323
  • [7] AN IMPROVED METHOD FOR CLONING PORTIONS OF THE REPEAT REGIONS OF HERPES-SIMPLEX VIRUS TYPE-1
    PERNG, GC
    GHIASI, H
    KAIWAR, R
    NESBURN, AB
    WECHSLER, SL
    JOURNAL OF VIROLOGICAL METHODS, 1994, 46 (02) : 111 - 116
  • [8] In vitro antiviral activity of styrylpyrone derivative-incorporated formulations against Herpes simplex virus type-1
    Bahtiar, Adibah Ahamad
    Nor, Norefrina Shafinaz Md
    Ibrahim, Nazlina
    MALAYSIAN JOURNAL OF MICROBIOLOGY, 2016, 12 (03) : 228 - 232
  • [9] The inhibitory effect of essential oils on herpes simplex virus type-1 replication in vitro
    Minami, M
    Kita, M
    Nakaya, T
    Yamamoto, T
    Kuriyama, H
    Imanishi, J
    MICROBIOLOGY AND IMMUNOLOGY, 2003, 47 (09) : 681 - 684
  • [10] Antiviral activity of theaflavin digallate against herpes simplex virus type 1
    de Oliveira, Aline
    Prince, Derek
    Lo, Chih-Yu
    Lee, Lee H.
    Chu, Tin-Chun
    ANTIVIRAL RESEARCH, 2015, 118 : 56 - 67
12345