The effect of antihypertensive treatment on the incidence of stroke and cognitive decline in the elderly: a meta-analysis

被引：20

作者：

Parsons, Christine ^{[1
]}

Murad, Mohammad Hassan ^{[2
]}

Andersen, Stuart ^{[1
]}

Mookadam, Farouk ^{[3
]}

Labonte, Helene ^{[1
]}

机构：

[1] Mayo Clin, Dept Internal Med, 5777 Mayo Blvd, Phoenix, AZ 85054 USA

[2] Mayo Clin, Div Prevent Med, 200 Ist St SW, Rochester, MN 55905 USA

[3] Mayo Clin, Div Cardiovasc Dis, 13400 Shea Blvd, Scottsdale, AZ 85259 USA

来源：

FUTURE CARDIOLOGY | 2016年 / 12卷 / 02期

关键词：

aged; cognition; dementia; hypertension; stroke;

D O I：

10.2217/fca.15.90

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To evaluate the effectiveness of antihypertensives in reducing neurocognitive outcomes in elderly patients. Patients & methods: We conducted a systematic literature search of randomized trials in which hypertensive patients with a mean age >= 65 years received antihypertensive or control treatment. Outcomes were stroke, transient ischemic attack, cognitive decline and dementia. We included 14 trials for meta-analysis. Results: Compared to placebo, antihypertensive treatment reduced the risk of stroke (RR: 0.67 [95% CI: 0.57-0.79]). Reduced risk was significant for transient ischemic attack, fatal stroke, nonfatal stroke and total stroke. There were insufficient data to compare individual agents. Conclusion: Antihypertensive treatment is associated with a significant reduction in stroke in elderly individuals. Reductions in dementia and cognitive decline were not significant; however, there was short follow-up. Comparative effectiveness evidence is limited.

引用

页码：237 / 248

页数：12

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