FORMULATION DEVELOPMENT AND EVALUATION OF ACECLOFENAC MICROEMULSION

被引：4

作者：

Bonthagarala, Brahmaiah ^{[1
]}

Murukutla, Venkatesh ^{[1
]}

Babu, Manohar S. ^{[1
]}

机构：

[1] SIMS Grp Inst, SIMS Coll Pharm, Dept Pharmaceut, Guntur 522001, Andhra Pradesh, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2016年 / 7卷 / 08期

关键词：

Aceclofenac; Microemulsion (ME); Optical transparency; Particle size; Transmission Electron Microscopy; in-vitroskin permeation; FT-IR;

D O I：

10.13040/IJPSR.0975-8232.7(8).3394-05

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of my present study is to Develop and Evaluate Microemulsion for topical application of Aceclofenac by using oleic acid at different ratios for the treatment of pain. Microemulsion was prepared by water trituration method using oleic acid as oil phase, tween-80 as surfactant and polyethylen glycol-400 as co-surfactant. Different oils, surfactants and co-surfactants were screened to select ideal components of microemulsions with good solubility and excellent skin penetration of Aceclofenac. The solubility of Aceclofenac was highest in oleic acid followed by olive oil, and isopropyl myristate, isopropyl palmitate. Microemulsion-3 (ME-3) was exhibited 98.54 +/- 0.26% higher drug content then other formulations. Among all formulations, the highest permeation flux of mu g/cm(2)/hour was observed in of formulation ME-3.

引用

页码：3394 / 3405

页数：12

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