SYNTHETIC VACCINES .1. SYNTHESIS OF MULTIVALENT TN ANTIGEN CLUSTER-LYSYLLYSINE CONJUGATES

被引：25

作者：

TOYOKUNI, T ^{[1
]}

DEAN, B ^{[1
]}

HAKOMORI, S ^{[1
]}

机构：

[1] UNIV WASHINGTON, SEATTLE, WA 98195 USA

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)94669-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Monomer, dimer, and trimer of Tn antigen (GalNAcα1→O-Ser) were coupled to L-lysyllysine to construct multivalent and clustering structures of Tn antigen. The method has made it possible to provide pertinent carbohydrate antigens for the development of synthetic vaccines against tumors. © 1990.

引用

收藏

页码：2673 / 2676

页数：4

相关论文

共 29 条

[1]

ADACHI T, 1977, SYNTHESIS-STUTTGART, P45

[2] SYNTHESIS OF GLYCOPEPTIDES HAVING CLUSTERS OF O-GLYCOSYLIC DISACCHARIDE CHAINS [BETA-D-GAL-(1-]3)-ALPHA-D-GALNAC] LOCATED AT VICINAL AMINO-ACID-RESIDUES OF THE PEPTIDE-CHAIN [J].

BENCOMO, VV ;

SINAY, P .

CARBOHYDRATE RESEARCH, 1983, 116 (02) :C9-C12

[3] INVIVO PRIMING OF VIRUS-SPECIFIC CYTO-TOXIC LYMPHOCYTES-T WITH SYNTHETIC LIPOPEPTIDE VACCINE [J].

DERES, K ;

SCHILD, H ;

WIESMULLER, KH ;

JUNG, G ;

RAMMENSEE, HG .

NATURE, 1989, 342 (6249) :561-564

[4]

DEREVITSKAYA V. A., 1967, CARBOHYD RES, V3, P377, DOI 10.1016/S0008-6215(00)82214-4

[5] A MULTIVALENT LACTO-N-FUCOPENTAOSE-III LYSYLLYSINE CONJUGATE DECOMPACTS PREIMPLANTATION MOUSE EMBRYOS, WHILE THE FREE OLIGOSACCHARIDE IS INEFFECTIVE [J].

FENDERSON, BA ;

ZEHAVI, U ;

HAKOMORI, SI .

JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 160 (05) :1591-1596

[6]

FERRARI B, 1983, INT J PEPT PROT RES, V22, P549

[7]

GRUNDLER G, 1984, LIEBIGS ANN CHEM, P1826

[8]

HAKOMORI S, 1985, CANCER RES, V45, P2405

[9]

HAKOMORI SI, 1989, ADV CANCER RES, V52, P257

[10] BLOOD-GROUP A CROSS-REACTING EPITOPE DEFINED BY MONOCLONAL-ANTIBODIES NCC-LU-35 AND NCC-LU-81 EXPRESSED IN CANCER OF BLOOD GROUP-O OR GROUP-B INDIVIDUALS - ITS IDENTIFICATION AS TN ANTIGEN [J].

HIROHASHI, S ;

CLAUSEN, H ;

YAMADA, T ;

SHIMOSATO, Y ;

HAKOMORI, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :7039-7043