THE CYP1A1 GENE AND CANCER SUSCEPTIBILITY

被引：225

作者：

KAWAJIRI, K ^{[1
]}

NAKACHI, K ^{[1
]}

IMAI, K ^{[1
]}

WATANABE, J ^{[1
]}

HAYASHI, S ^{[1
]}

机构：

[1] SAITAMA CANC CTR,RES INST,DEPT EPIDEMIOL,INA,SAITAMA 362,JAPAN

来源：

CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY | 1993年 / 14卷 / 01期

关键词：

D O I：

10.1016/1040-8428(93)90007-Q

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1). Interindividual variability in the genetic make-up of carcinogen metabolizing enzymes may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals. © 1993.

引用

页码：77 / 87

页数：11

共 91 条

[31] THE POLYMORPHIC EXPRESSION OF NEUTRAL GLUTATHIONE-S-TRANSFERASE IN HUMAN MONONUCLEAR LEUKOCYTES AS MEASURED BY SPECIFIC RADIOIMMUNOASSAY [J].

HUSSEY, AJ ;

HAYES, JD ;

BECKETT, GJ .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (22) :4013-4015

[32] IS ENVIRONMENTAL CARCINOGENESIS MODULATED BY HOST POLYMORPHISM [J].

IDLE, JR .

MUTATION RESEARCH, 1991, 247 (02) :259-266

[33] HUMAN CYP1A2 - SEQUENCE, GENE STRUCTURE, COMPARISON WITH THE MOUSE AND RAT ORTHOLOGOUS GENE, AND DIFFERENCES IN LIVER 1A2 MESSENGER-RNA EXPRESSION [J].

IKEYA, K ;

JAISWAL, AK ;

OWENS, RA ;

JONES, JE ;

NEBERT, DW ;

KIMURA, S .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (09) :1399-1408

[34] 2 REGULATORY PROTEINS THAT BIND TO THE BASIC TRANSCRIPTION ELEMENT (BTE), A GC BOX SEQUENCE IN THE PROMOTER REGION OF THE RAT P-4501A1 GENE [J].

IMATAKA, H ;

SOGAWA, K ;

YASUMOTO, K ;

KIKUCHI, Y ;

SASANO, K ;

KOBAYASHI, A ;

HAYAMI, M ;

FUJIIKURIYAMA, Y .

EMBO JOURNAL, 1992, 11 (10) :3663-3671

[35] HUMAN P1-450 GENE SEQUENCE AND CORRELATION OF MESSENGER-RNA WITH GENETIC-DIFFERENCES IN BENZO[A]PYRENE METABOLISM [J].

JAISWAL, AK ;

GONZALEZ, FJ ;

NEBERT, DW .

NUCLEIC ACIDS RESEARCH, 1985, 13 (12) :4503-4520

[36] HUMAN DIOXIN-INDUCIBLE CYTOCHROME-P1-450 - COMPLEMENTARY-DNA AND AMINO-ACID SEQUENCE [J].

JAISWAL, AK ;

GONZALEZ, FJ ;

NEBERT, DW .

SCIENCE, 1985, 228 (4695) :80-83

[37]

KAWAJIRI K, 1984, J BIOL CHEM, V259, P145

[38] P450 AND HUMAN CANCER [J].

KAWAJIRI, K ;

FUJIIKURIYAMA, Y .

JAPANESE JOURNAL OF CANCER RESEARCH, 1991, 82 (12) :1325-1335

[39]

KAWAJIRI K, 1991, XENOBIOTICS AND CANCER, P55

[40] STRUCTURE AND DRUG INDUCIBILITY OF THE HUMAN CYTOCHROME-P-450C GENE [J].

KAWAJIRI, K ;

WATANABE, J ;

GOTOH, O ;

TAGASHIRA, Y ;

SOGAWA, K ;

FUJIIKURIYAMA, Y .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 159 (02) :219-225

← 1 2 3 4 5 6 7 8 9 10 →