GLUTAMIC-ACID AND ETHANOL DEPENDENCE

被引：56

作者：

FREED, WJ ^{[1
]}

MICHAELIS, EK ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT HUMAN DEV,LAWRENCE,KS 66045

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1978年 / 8卷 / 05期

关键词：

Alcohol addiction; Central denervation supersensitivity; Ethanol dependence; Ethanol withdrawal; Glutamic acid; Glutamic acid diethyl ester; Kainic acid; Mechanisms of drug dependence; Pentylenetetrazol;

D O I：

10.1016/0091-3057(78)90379-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Glutamate diethyl ester, a specific glutamate antagonist, attenuated the seizures and decreases in behavioral activity that were observed in mice during withdrawal. Prior to withdrawal, ethanol-dependent animals were supersensitive to kainic acid, a potent glutamate agonist, but they were not supersensitive to the convulsant drug pentylenetetrazol. These findings suggest that supersensitivity to glutamate develops during ethanol dependence, and that this phenomenon contributes to the signs of ethanol withdrawal. © 1978.

引用

页码：509 / 514

页数：6

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