EFFECT OF HUMAN GALANIN ON GROWTH-HORMONE PROLACTIN AND ANTIDIURETIC-HORMONE SECRETION IN NORMAL MEN

被引：15
作者：
MURAKAMI, Y
OHSHIMA, K
MOCHIZUKI, T
YANAIHARA, N
机构：
[1] SHIZUOKA CITY HOSP, ENDOCRINE DIS CLIN, SHIZUOKA, SHIZUOKA 420, JAPAN
[2] UNIV SHIZUOKA, SCH PHARMACEUT SCI, BIOORGAN CHEM LAB, SHIZUOKA, SHIZUOKA 422, JAPAN
来源：
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1993年 / 77卷 / 05期
关键词：
D O I：
10.1210/jc.77.5.1436
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Galanin is a brain-gut peptide occurring widely in the central and peripheral nervous system. Effects of iv administration of synthetic human galanin on pituitary GH, PRL, and antidiuretic hormone secretion were studied. Intravenous infusion of the peptide resulted in a significant increase in plasma GH levels whereas PRL and antidiuretic hormone did not significantly change. These findings suggest that galanin might play a role in modulating GH secretion in humans.
引用
收藏
页码：1436 / 1438
页数：3
相关论文
共 17 条
[1]  
BAUER FE, 1986, LANCET, V2, P192
[2]   HUMAN GALANIN - PRIMARY STRUCTURE AND IDENTIFICATION OF 2 MOLECULAR-FORMS [J].
BERSANI, M ;
JOHNSEN, AH ;
HOJRUP, P ;
DUNNING, BE ;
ANDREASEN, JJ ;
HOLST, JJ .
FEBS LETTERS, 1991, 283 (02) :189-194
[3]   DISTRIBUTION OF GALANIN IMMUNOREACTIVITY IN THE CENTRAL NERVOUS-SYSTEM AND THE RESPONSES OF GALANIN-CONTAINING NEURONAL PATHWAYS TO INJURY [J].
CHNG, JLC ;
CHRISTOFIDES, ND ;
ANAND, P ;
GIBSON, SJ ;
ALLEN, YS ;
SU, HC ;
TATEMOTO, K ;
MORRISON, JFB ;
POLAK, JM ;
BLOOM, SR .
NEUROSCIENCE, 1985, 16 (02) :343-354
[4]   GALANIN SECRETION FROM ANTERIOR-PITUITARY-CELLS INVITRO IS REGULATED BY DOPAMINE, SOMATOSTATIN, AND THYROTROPIN-RELEASING-HORMONE [J].
HYDE, JF ;
KELLER, BK .
ENDOCRINOLOGY, 1991, 128 (02) :917-922
[5]   CARDIOVASCULAR AND RESPIRATORY ACTIONS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDES [J].
ISHIZUKA, Y ;
KASHIMOTO, K ;
MOCHIZUKI, T ;
SATO, K ;
OHSHIMA, K ;
YANAIHARA, N .
REGULATORY PEPTIDES, 1992, 40 (01) :29-39
[6]   CENTRAL GALANIN STIMULATES PITUITARY PROLACTIN SECRETION IN RATS - POSSIBLE INVOLVEMENT OF HYPOTHALAMIC VASOACTIVE INTESTINAL POLYPEPTIDE [J].
KOSHIYAMA, H ;
KATO, Y ;
INOUE, T ;
MURAKAMI, Y ;
ISHIKAWA, Y ;
YANAIHARA, N ;
IMURA, H .
NEUROSCIENCE LETTERS, 1987, 75 (01) :49-54
[7]   SEQUENCE OF HUMAN GALANIN AND ITS INHIBITION OF GLUCOSE-STIMULATED INSULIN-SECRETION FROM RIN CELLS [J].
MCKNIGHT, GL ;
KARLSEN, AE ;
KOWALYK, S ;
MATHEWES, SL ;
SHEPPARD, PO ;
OHARA, PJ ;
TABORSKY, GJ .
DIABETES, 1992, 41 (01) :82-87
[8]   GALANIN STIMULATES GROWTH-HORMONE (GH) SECRETION VIA GH-RELEASING FACTOR (GRF) IN CONSCIOUS RATS [J].
MURAKAMI, Y ;
KATO, Y ;
KOSHIYAMA, H ;
INOUE, T ;
YANAIHARA, N ;
IMURA, H .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 136 (03) :415-418
[9]   POSSIBLE MECHANISMS INVOLVED IN GROWTH-HORMONE SECRETION INDUCED BY GALANIN IN THE RAT [J].
MURAKAMI, Y ;
KATO, Y ;
SHIMATSU, A ;
KOSHIYAMA, H ;
HATTORI, N ;
YANAIHARA, N ;
IMURA, H .
ENDOCRINOLOGY, 1989, 124 (03) :1224-1229
[10]  
MURAKAMI Y, 1988, NEUROENDOCRINE CONTR, P85
12