HOMOLOGATION OF L-PHENYLALANINE TO KETOMETHYLENE AND HYDROXYETHYLENE DIPEPTIDE ISOSTERES VIA 2-THIAZOLYL AMINO KETONE INTERMEDIATE

被引：27
作者：
DONDONI, A
PERRONE, D
机构：
[1] Dipartimento di Chimica, Laboratorio di Chimica Organica, Università, Ferrara
来源：
TETRAHEDRON LETTERS | 1992年 / 33卷 / 47期
关键词：
THIAZOLE; L-PHENYLALANINE; HOMOLOGATION; DIPEPTIDE ISOSTERS;
D O I：
10.1016/S0040-4039(00)60888-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient route is presented for the synthesis of N-protected isosteric dipeptides Phepsi[COCH2]Gly and Phepsi[CH(OH)CH2]Phe from L-phenylalanine through 2-thiazolyl alpha-amino ketone and delta-amino-gamma-hydroxy-(E)-alpha,beta-enoate derivatives as key intermediates.
引用
收藏
页码：7259 / 7262
页数：4
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