INTERLEUKIN-7 - A COFACTOR FOR V(D)J REARRANGEMENT OF THE T-CELL RECEPTOR BETA-GENE

被引：208
作者：
MUEGGE, K [1 ]
VILA, MP [1 ]
DURUM, SK [1 ]
机构：
[1] NCI,BIOL RESPONSE MODIFIERS PROGRAM,MOLEC IMMUNOREGULAT LAB,FREDERICK,MD 21702
来源：
SCIENCE | 1993年 / 261卷 / 5117期
关键词：
D O I：
10.1126/science.7686307
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The diversity of the T cell receptor repertoire is generated by rearrangement of gene elements in immature thymocytes. To identify a thymic signal that induces this rearrangement, a variety of agents were tested for their ability to induce rearrangement of the T cell receptor beta gene in suspensions of thymocytes from mouse embryos at day 14 of gestation. Of 16 agents tested, only interleukin-7 (IL-7) induced V(D)J gene rearrangement and sustained expression of the RAG-1 and RAG-2 genes, which are known to control rearrangement. These data implicate IL-7, a cytokine that is abundantly expressed in embryonic thymus, in driving gene rearrangement during early T cell development.
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页码：93 / 95
页数：3
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