ENHANCEMENT OF HUMAN IMMUNODEFICIENCY VIRUS-1 REPLICATION IN MONOCYTES BY 1,25-DIHYDROXYCHOLECALCIFEROL

被引：42
作者：
SKOLNIK, PR
JAHN, B
WANG, MZ
ROTA, TR
HIRSCH, MS
KRANE, SM
机构：
[1] NEW ENGLAND MED CTR HOSP,DIV GEOG MED & INFECT DIS,BOSTON,MA 02111
[2] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115
[3] MASSACHUSETTS GEN HOSP,ARTHRITIS UNIT,BOSTON,MA 02114
[4] MASSACHUSETTS GEN HOSP,INFECT DIS UNIT,BOSTON,MA 02114
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 15期
关键词：
AIDS; VITAMIN-D; CALCITRIOL;
D O I：
10.1073/pnas.88.15.6632
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human immunodeficiency virus (HIV) expression and replication are under tight regulatory control. We demonstrate that 1,25-dihydroxycholecalciferol [1,25(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells. 1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date. Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor. These studies may have important implications for the design of effective therapy of HIV-1 infection.
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页码：6632 / 6636
页数：5
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