CONTROL OF NEURONAL EXCITABILITY BY CORTICOSTEROID HORMONES

被引：372
作者：
JOELS, M [1 ]
DEKLOET, ER [1 ]
机构：
[1] LEIDEN UNIV,CTR BIOPHARMACEUT SCI,2300 RA LEIDEN,NETHERLANDS
来源：
TRENDS IN NEUROSCIENCES | 1992年 / 15卷 / 01期
关键词：
D O I：
10.1016/0166-2236(92)90345-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The rat adrenal hormone corticosterone can cross the blood-brain barrier and bind to two intracellular receptor populations in the brain - the mineralocorticoid and glucocorticoid receptor. Recent studies have revealed that the corticosteroid hormones are able to restore changes in neuronal membrane properties induced by current or neurotransmitters, probably through a genomic action. In general, mineralocorticoid receptors mediate steroid actions that enhance cellular excitability, whereas activated glucocorticoid receptors can suppress temporarily raised neuronal activity. The steroid-mediated control of excitability and the implications for information processing in the brain are reviewed in this article.
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页码：25 / 30
页数：6
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