ELEVATED CORTICOSTERONE LEVELS IN TRANSGENIC MICE EXPRESSING HUMAN OR BOVINE GROWTH-HORMONE GENES

被引：44
作者：
CECIM, M
GHOSH, PK
ESQUIFINO, AI
BEGAN, T
WAGNER, TE
YUN, JS
BARTKE, A
机构：
[1] SO ILLINOIS UNIV,SCH MED,DEPT PHYSIOL,CARBONDALE,IL 62901
[2] UNIV COMPLUTENSE MADRID,FAC MED,DEPT BIOCHEM,MADRID 3,SPAIN
[3] OHIO UNIV,EDISON ANIM BIOTECHNOL CTR,ATHENS,OH 45701
来源：
NEUROENDOCRINOLOGY | 1991年 / 53卷 / 03期
关键词：
CORTICOSTERONE; TRANSGENIC MICE; GROWTH HORMONE; STRESS;
D O I：
10.1159/000125734
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ectopic expression of human or bovine growth hormone (GH) genes in 6 lines of transgenic mice was associated with a significant increase in plasma corticosterone levels. Elevated corticosterone levels were detected in both sexes under basal conditions and after ether stress. The adrenal activity of 3-beta-hydroxysteroid dehydrogenase was measured in two of these lines and was found to be significantly increased in transgenic animals. Plasma corticosterone levels in transgenic mice did not correlate with known differences between the various lines in male and female fertility or in the life span.
引用
收藏
页码：313 / 316
页数：4
相关论文
共 16 条
[1]  
BARTKE A, 1990, NEUROENDOCRINOLOGY : NEW FRONTIERS, P39
[2]   EFFECT OF CORTICOSTERONE ON ADRENAL 5-ENE-3-BETA-HYDROXYSTEROID DEHYDROGENASE IN ESTROGEN-TREATED RATS [J].
GHOSH, PK ;
BISWAS, NM .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1983, 19 (03) :1309-1312
[3]   GROWTH-PROMOTING AND LUTEOTROPHIC ACTIVITIES OF HUMAN GROWTH HORMONE [J].
HARTREE, AS ;
KOVACIC, N ;
THOMAS, M .
JOURNAL OF ENDOCRINOLOGY, 1965, 33 (02) :249-&
[4]   HIPPOCAMPAL AGING AND ADRENOCORTICOIDS - QUANTITATIVE CORRELATIONS [J].
LANDFIELD, PW ;
WAYMIRE, JC ;
LYNCH, G .
SCIENCE, 1978, 202 (4372) :1098-1102
[5]   EFFECTS OF TRANSGENES FOR HUMAN AND BOVINE GROWTH-HORMONES ON AGE-RELATED-CHANGES IN OVARIAN MORPHOLOGY IN MICE [J].
MAYERHOFER, A ;
WEIS, J ;
BARTKE, A ;
YUN, JS ;
WAGNER, TE .
ANATOMICAL RECORD, 1990, 227 (02) :175-186
[6]  
MCGRANE MM, 1988, J BIOL CHEM, V263, P11443
[7]   THE HUMAN PLACENTAL GROWTH-HORMONE VARIANT IS MITOGENIC FOR RAT LYMPHOMA NB2 CELLS [J].
NICKEL, BE ;
KARDAMI, E ;
CATTINI, PA .
ENDOCRINOLOGY, 1990, 126 (02) :971-976
[8]   CHARACTERIZATION OF INSULIN-LIKE GROWTH FACTOR-I AND INSULIN-RECEPTORS ON CULTURED BOVINE ADRENAL FASCICULATA CELLS - ROLE OF THESE PEPTIDES ON ADRENAL-CELL FUNCTION [J].
PENHOAT, A ;
CHATELAIN, PG ;
JAILLARD, C ;
SAEZ, JM .
ENDOCRINOLOGY, 1988, 122 (06) :2518-2526
[9]   STRESS-INDUCED SUPPRESSION OF TESTICULAR FUNCTION IN THE WILD BABOON - ROLE OF GLUCOCORTICOIDS [J].
SAPOLSKY, RM .
ENDOCRINOLOGY, 1985, 116 (06) :2273-2278
[10]   GLUCOCORTICOID REGULATION OF HUMAN GROWTH-HORMONE EXPRESSION IN TRANSGENIC MICE AND TRANSIENTLY TRANSFECTED CELLS [J].
SELDEN, RF ;
YUN, JS ;
MOORE, DD ;
ROWE, ME ;
MALIA, MA ;
WAGNER, TE ;
GOODMAN, HM .
JOURNAL OF ENDOCRINOLOGY, 1989, 122 (01) :49-60
12