DOSIMETRY FOR RADIATION ACCIDENTS - PRESENT STATUS AND PROSPECTS FOR BIOLOGICAL DOSIMETERS

被引：31

作者：

ZOETELIEF, J ^{[1
]}

BROERSE, JJ ^{[1
]}

机构：

[1] DEPT CLIN ONCOL,2300 RC LEIDEN,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1990年 / 57卷 / 04期

关键词：

D O I：

10.1080/09553009014550901

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The induction of chromosome aberrations in human peripheral blood lymphocytes is still the most useful dosimetry system for accidental whole-body irradiation; however, in the case of a very large number of casualties the micronuclei technique might provide advantages. For partial-body irradiations, determination of hair diameter and chromosome aberrations in skin fibroblasts and hair might be advantageous, since better information on dose distribution might be obtained. The latter cytological techniques are complex and require considerable culture time. Flow cytometry for determination of chromosome aberrations, a staining technique for hair follicles and an immunochemical method for quantitative detection of persistent DNA damage in mammalian cells might be applicable in the future. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：737 / 750

页数：14

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