MOST EFFICIENT INTRAMOLECULAR GENERAL ACID CATALYSIS OF ACETAL HYDROLYSIS BY THE CARBOXY GROUP

被引：35
|
作者：
KIRBY, AJ
PARKINSON, A
机构：
来源：
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 06期
关键词：
D O I：
10.1039/c39940000707
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The hydrolysis of 4-methoxymethoxybenzisoxazole-3-carboxylic acid (halflife 31 s at 39-degrees-C) is the fastest measured for a methoxymethyl acetal: catalysis by the neighbouring CO2H group is facilitated by a strong intramolecular hydrogen bond.
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页码：707 / 708
页数：2
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