MOLECULAR AND FUNCTIONAL-ANALYSIS OF A LYMPHOCYTE CHEMOATTRACTANT FACTOR - ASSOCIATION OF BIOLOGIC FUNCTION WITH CD4 EXPRESSION

被引：248
作者：
CRUIKSHANK, WW
CENTER, DM
NISAR, N
WU, MN
NATKE, B
THEODORE, AC
KORNFELD, H
机构：
[1] Pulmonary Center, Boston University, School of Medicine, Boston
[2] Pulmonary Center, K-600, Boston University Medical Center, Boston, MA 02118
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 11期
关键词：
D O I：
10.1073/pnas.91.11.5109
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4(+) lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.
引用
收藏
页码：5109 / 5113
页数：5
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