A POSSIBLE ROLE FOR BCL-2 IN REGULATING T-CELL MEMORY - A BALANCING ACT BETWEEN CELL-DEATH AND SURVIVAL

被引：120

作者：

AKBAR, AN

SALMON, M

SAVILL, J

JANOSSY, G

机构：

[1] UNIV BIRMINGHAM, SCH MED, DEPT RHEUMATOL, BIRMINGHAM B15 2TJ, W MIDLANDS, ENGLAND

[2] HAMMERSMITH HOSP, ROYAL POSTGRAD MED SCH, DEPT MED, RENAL UNIT, LONDON W12 0HS, ENGLAND

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 11期

关键词：

D O I：

10.1016/0167-5699(93)90181-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One of the central questions in T-cell immunity is how the generation of T-cell memory may proceed simultaneously with the maintenance of T-cell homeostasis. In this article, we present a hypothesis that the regulation of bcl-2 gene expression within the activated CD4SRO+ T-cell population may be one of the key factors in the balance between death and survival of these activated mature T cells, both in vitro and in vivo.

引用

页码：526 / 532

页数：7

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