A 25 Immune-Related Gene Pair Signature Predicts Overall Survival in Cervical Cancer

被引：0
作者：
Chen, Huaqiu [1 ,2 ]
Xie, Huanyu [2 ]
Wang, Pengyu [1 ]
Yan, Shanquan [1 ]
Zhang, Yuanyuan [1 ]
Wang, Guangming [1 ]
机构：
[1] Dali Univ, Sch Clin Med, Dali, Yunnan, Peoples R China
[2] Xichang Peoples Hosp, Xichang, Sichuan, Peoples R China
来源：
CANCER INFORMATICS | 2022年 / 21卷
关键词：
Cervical cancer; immune cell infiltration; prognostic signature; immune-related gene pairs; overall survival; prognosis;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mounting evidence suggests that the tumor microenvironment plays an important role in the occurrence and development of cancer, with immune system dysfunction being closely related to malignant cancers. We aimed to screen immune-related genes (IRGs) to generate an IRG pair (IRGP)-based prognostic signature for cervical cancer (CC). Datasets were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases and used as training and validation cohorts, respectively. Using the ImmPort database, IRGs in control and CC samples were compared, and differentially expressed genes were identified to construct an IRGP prognostic signature. Based on this analysis, 25 IRGPs were identified as important factors for the prognosis of CC. Univariate and multivariate Cox regression analyses further showed that the IRGP signature was an independent prognostic factor of overall survival. In summary, we successfully constructed an IRGP prognostic signature of CC, providing insights into immunotherapy for CC.
引用
收藏
页数：9
相关论文
共 37 条
[1]   From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer [J].
Angel, Helen ;
Galon, Jerome .
CURRENT OPINION IN IMMUNOLOGY, 2013, 25 (02) :261-267
[2]   Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis [J].
Arbyn, Marc ;
Weiderpass, Elisabete ;
Bruni, Laia ;
de Sanjose, Silvia ;
Saraiya, Mona ;
Ferlay, Jacques ;
Bray, Freddie .
LANCET GLOBAL HEALTH, 2020, 8 (02) :E191-E203
[3]   Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer [J].
Battaglia, Alessandra ;
Buzzonetti, Alexia ;
Monego, Giovanni ;
Peri, Laura ;
Ferrandina, Gabriella ;
Fanfani, Francesco ;
Scambia, Giovanni ;
Fattorossi, Andrea .
IMMUNOLOGY, 2008, 123 (01) :129-138
[4]   Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].
Bray, Freddie ;
Ferlay, Jacques ;
Soerjomataram, Isabelle ;
Siegel, Rebecca L. ;
Torre, Lindsey A. ;
Jemal, Ahmedin .
CA-A CANCER JOURNAL FOR CLINICIANS, 2018, 68 (06) :394-424
[5]   A signature of 13 autophagy-related gene pairs predicts prognosis in hepatocellular carcinoma [J].
Cao, Jie ;
Wu, Lili ;
Lei, Xin ;
Shi, Keqing ;
Shi, Liang .
BIOENGINEERED, 2021, 12 (01) :697-707
[6]   Induction of systemic immune responses and reversion of immunosuppression in the tumor microenvironment by a therapeutic vaccine for cervical cancer [J].
Che, Yuxin ;
Yang, Yang ;
Suo, Jinguo ;
An, Yujing ;
Wang, Xuelian .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2020, 69 (12) :2651-2664
[7]   Oncology Meets Immunology: The Cancer-Immunity Cycle [J].
Chen, Daniel S. ;
Mellman, Ira .
IMMUNITY, 2013, 39 (01) :1-10
[8]   NRP1 regulates radiation-induced EMT via TGF-β/Smad signaling in lung adenocarcinoma cells [J].
Chen, ZhiYuan ;
Gao, Hui ;
Dong, Zhuo ;
Shen, YanNan ;
Wang, ZhiCheng ;
Wei, Wei ;
Yi, JunXuan ;
Wang, Rui ;
Wu, Ning ;
Jin, Shunzi .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2020, 96 (10) :1281-1295
[9]   The immune contexture in cancer prognosis and treatment [J].
Fridman, Wolf H. ;
Zitvogel, Laurence ;
Sautes-Fridman, Catherine ;
Kroemer, Guido .
NATURE REVIEWS CLINICAL ONCOLOGY, 2017, 14 (12) :717-734
[10]   Recurrent Loss of APOBEC3H Activity during Primate Evolution [J].
Garcia, Erin I. ;
Emerman, Michael .
JOURNAL OF VIROLOGY, 2018, 92 (17)
1234