EFFECTS OF GLUCOSE ON CALCIUM CHANNELS IN NEURAL CELLS

被引:8
作者
CHAN, J
GREENBERG, DA
机构
[1] UNIV CALIF SAN FRANCISCO,SAN FRANCISCO GEN HOSP,DEPT NEUROL,4M62,SAN FRANCISCO,CA 94110
[2] UNIV CALIF SAN FRANCISCO,DIV CLIN PHARMACOL & EXPTL THERAPEUT,SAN FRANCISCO,CA 94143
关键词
CALCIUM; CALCIUM CHANNEL; GLUCOSE; ISCHEMIA; PC; 12; CELL;
D O I
10.1016/0304-3940(91)90642-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hyperglycemia has been reported to alter outcome following experimental and clinical cerebral ischemia, but the mechanisms involved are incompletely understood. Since glucose influences the function of dihydropyridine-sensitive, voltage-gated Ca2+ channels in some non-neural cells, and since cellular Ca2+ overload has been implicated in the pathogenesis of ischemic neuronal injury, we examined whether glucose regulates Ca2+ channel function in a cultured neural cell line. Physiologic concentrations of glucose had no effect on free intracellular Ca2+ levels in PC12 cells, but 4-fold elevation of glucose above physiologic levels reduced the dihydropyridine-sensitive, depolarization-induced increase in Ca2+. This effect would not account for exacerbation of ischemic brain injury by hyperglycemia, but may contribute to attenuation of ischemic injury by glucose in certain settings.
引用
收藏
页码:34 / 36
页数:3
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