SYNAPTOPHYSIN EXPRESSION IN THE STRIATUM IN HUNTINGTONS-DISEASE

被引：32
作者：
GOTO, S [1 ]
HIRANO, A [1 ]
机构：
[1] MONTEFIORE MED CTR,DIV NEUROPATHOL,BLUESTONE LAB,III E 210TH ST,BRONX,NY 10467
来源：
ACTA NEUROPATHOLOGICA | 1990年 / 80卷 / 01期
关键词：
Calcineurin; Huntington's disease; Immunohistochemistry; Striatum; Synaptophysin;
D O I：
10.1007/BF00294227
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This immunohistochemical study compares the expression of synaptophysin (SYP) in the striatum in Huntington's disease (HD) with that of calcineurin (CaN), a marker for striatal medium-sized spinous neurons. As compared to controls, in the HD striatum there was a significant loss of SYP immunoreactivity with residual staining displaying an inhomogeneous pattern, which strikingly resembled that of CaN. Our results may indicate that there is a synaptic loss in the striatum with HD and this is most likely due to loss of medium-sized spinous neurons characteristic of this disease. © 1990 Springer-Verlag.
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页码：88 / 91
页数：4
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