PROTHROMBIN ANTIBODY COEXISTENT WITH LUPUS ANTICOAGULANT (LA) - CLINICAL-STUDY AND IMMUNOCHEMICAL CHARACTERIZATION

被引：18

作者：

BAUDO, F ^{[1
]}

REDAELLI, R ^{[1
]}

PEZZETTI, L ^{[1
]}

CAIMI, TM ^{[1
]}

BUSNACH, G ^{[1
]}

PERRINO, L ^{[1
]}

DECATALDO, F ^{[1
]}

机构：

[1] OSPED MAGGIORE CA GRANDA,DEPT NEPHROL,MILAN,ITALY

来源：

THROMBOSIS RESEARCH | 1990年 / 57卷 / 02期

关键词：

hypoprothrombinemia; lupus anticoagulant; prothrombin antibody;

D O I：

10.1016/0049-3848(90)90327-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The patient is a 23 y.o. man with acute nephritis and bleeding at presentation. Laboratory data consistent with the diagnosis of systemic lupus erythematosus. A lupus anticoagulant was found: tissue thromboplast in inhibition test (TTIT) ratio 3.4; diluted Russell viper venom (DRVV) ratio 2.6. Hypoprothrombinemia (FII:C > 1%; FIIR:Ag 5%) was present; prothrombin survival time (FII concentrate infusion 60 U/kg): t 1 2≈9 hours. A prothrombin antibody was identified: it is not neutralizing but forms an immunecomplex with prothrombin. The antibody was characterized as IgG2, IgA, k, A . The prothrombin survival time indicates that the hypoprothrombinemia is due to the clearance of the prothrombin-antiprothrombin complex in vivo. © 1990.

引用

页码：279 / 287

页数：9

共 12 条

[1]

BAJAJ SP, 1983, BLOOD, V61, P684

[2] A SIMPLIFIED PROCEDURE FOR PURIFICATION OF HUMAN-PROTHROMBIN, FACTOR-IX AND FACTOR-X [J].