NMR-STUDIES OF A PLANT FLAVONOID DNA OLIGONUCLEOTIDE COMPLEX

被引：0
|
作者：
NERDAL, W
ANDERSEN, OM
SLETTEN, E
机构：
[1] Department of Chemistry, University of Bergen
来源：
ACTA CHEMICA SCANDINAVICA | 1993年 / 47卷 / 07期
关键词：
D O I：
10.3891/acta.chem.scand.47-0658
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A structural model of the solution complex between a flavonoid and a DNA dodecamer containing the E. coli wild-type lac promoter sequence (TATGTT) was obtained using simulated annealing for refinement. The distance constraints were derived from NOESY NMR spectra. The minor groove binding of this flavonoid displays possible hydrogen bonds to the DNA, and these can take part in complex formation. This work is the first description of how a molecule of this class of natural compounds may interact with DNA.
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页码：658 / 662
页数：5
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