BENZODIAZEPINES INCREASE PREPROCHOLECYSTOKININ MESSENGER-RNA LEVELS IN RAT-BRAIN

被引：20

作者：

RATTRAY, M ^{[1
]}

SINGHVI, S ^{[1
]}

WU, PY ^{[1
]}

ANDREWS, N ^{[1
]}

FILE, SE ^{[1
]}

机构：

[1] UNIV LONDON,UMDS,GUYS HOSP,DIV PHARMACOL,PSYCHOPHARMACOL RES UNIT,LONDON,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1993年 / 245卷 / 02期

基金：

英国惠康基金;

关键词：

INSITU HYBRIDIZATION; CHOLECYSTOKININ (CCK); DIAZEPAM; TOLERANCE; WITHDRAWAL; MESSENGER RNA;

D O I：

10.1016/0922-4106(93)90129-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using in situ hybirdisation, the effects of acute and chronic diazepam administration and diazepam withdrawal on preprocholecystokinin (CCK) mRNA levels in discrete regions of rat brain were determined. In cerebral cortex and a subpopulation of hippocampal neurones, CCK mRNA levels were increased after a single injection of diazepam and 24 h after withdrawal from chronic diazepam treatment, but not after chronic diazepam treatment. These results show that, in some neuronal groups, CCK mRNA expression is regulated by benzodiazepines, although there is no clear link between CCK mRNA levels and anxiety state.

引用

页码：193 / 196

页数：4

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