IDIOPATHIC PULMONARY FIBROSIS AND HEPATITIS-C VIRUS-INFECTION

被引：88

作者：

IRVING, WL ^{[1
]}

DAY, S ^{[1
]}

JOHNSTON, IDA ^{[1
]}

机构：

[1] UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT MICROBIOL & RESP MED,NOTTINGHAM NG7 2UH,ENGLAND

来源：

AMERICAN REVIEW OF RESPIRATORY DISEASE | 1993年 / 148卷 / 06期

关键词：

D O I：

10.1164/ajrccm/148.6_Pt_1.1683

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

A possible role for hepatitis C virus (HCV) infection in the pathogenesis of idiopathic pulmonary fibrosis (IPF) has recently been suggested on the basis of an unusually high seroprevalence rate of anti-HCV in such patients from Japan. In an attempt to confirm these findings, we tested sera from 62 patients with IPF by two second-generation anti-HCV ELISAs. Only one serum was reactive. Serum from this patient gave an indeterminate result when tested by four-antigen RIBA (c22 band only), and it was negative for the presence of HCV RNA when tested by the reverse transcriptase polymerase chain reaction assay. HCV infection is thus no more prevalent in patients with IPF from the UK than in the general population.

引用

页码：1683 / 1684

页数：2

共 8 条

[1] HCV CONFIRMATORY TESTING OF BLOOD-DONORS [J].

FOLLETT, EAC ;

DOW, BC ;

MCOMISH, F ;

YAP, PL ;

HUGHES, W ;

MITCHELL, R ;

SIMMONDS, P .

LANCET, 1991, 338 (8773) :1024-1024

[2] HCV AND PCR NEGATIVITY [J].

IRVING, WL ;

DAY, S ;

EGLIN, RP ;

BENNETT, DP ;

JONES, DA ;

NUTTALL, P ;

JAMES, V .

LANCET, 1992, 339 (8806) :1425-1425

[3]

IRVING WL, 1993, LANCET, V340, P635

[4] RISING MORTALITY FROM CRYPTOGENIC FIBROSING ALVEOLITIS [J].

JOHNSTON, I ;

BRITTON, J ;

KINNEAR, W ;

LOGAN, R .

BRITISH MEDICAL JOURNAL, 1990, 301 (6759) :1017-1021

[5] HEPATITIS-C VIRUS-ANTIBODIES IN CHRONIC ACTIVE HEPATITIS - PATHOGENETIC FACTOR OR FALSE-POSITIVE RESULT [J].

MCFARLANE, IG ;

SMITH, HM ;

JOHNSON, PJ ;

BRAY, GP ;

VERGANI, D ;

WILLIAMS, R .

LANCET, 1990, 335 (8692) :754-757

[6] CRYPTOGENIC FIBROSING ALVEOLITIS - RESPONSE TO CORTICOSTEROID TREATMENT AND ITS EFFECT ON SURVIVAL [J].

TURNERWARWICK, M ;

BURROWS, B ;

JOHNSON, A .

THORAX, 1980, 35 (08) :593-599

[7] AUTO-ANTIBODY STUDIES IN INTERSTITIAL PULMONARY FIBROSIS [J].

TURNERWARWICK, M ;

DONIACH, D .

BMJ-BRITISH MEDICAL JOURNAL, 1965, 1 (5439) :886-+

[8] IDIOPATHIC PULMONARY FIBROSIS AND HIGH PREVALENCE OF SERUM ANTIBODIES TO HEPATITIS-C VIRUS [J].

UEDA, T ;

OHTA, K ;

SUZUKI, N ;

YAMAGUCHI, M ;

HIRAI, K ;

HORIUCHI, T ;

WATANABE, J ;

MIYAMOTO, T ;

ITO, K .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (01) :266-268

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