EFFECTS OF THE PYRIMIDINE-CONTAINING CYTOCHROME-P-450 INHIBITOR, FENARIMOL, ON THE FORMATION OF 20-OH ECDYSONE IN FLIES

被引：9

作者：

KULCSAR, P

DARVAS, B

BRANDTNER, H

KOOLMAN, J

REES, HH

机构：

[1] UNIV MARBURG,INST PHYSIOL CHEM,W-3550 MARBURG,GERMANY

[2] UNIV LIVERPOOL,DEPT BIOCHEM,LIVERPOOL L69 3BX,ENGLAND

来源：

EXPERIENTIA | 1991年 / 47卷 / 03期

关键词：

CALLIPHORA-VICINA; NEOBELLIERIA-BULLATA; FENARIMOL; SYNTHESIS OF 20-HYDROXY ECDYSONE; CYTOCHROME-P-450; INHIBITOR; MICROSOMAL ECDYSONE 20-MONOOXYGENASE;

D O I：

10.1007/BF01958154

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of fenarimol, a pyrimidine-containing cytochrome P-450 inhibitor, was tested in vitro on brain-ring gland complexes of Calliphora vicina (Dipt., Calliphoridae), and on microsomes prepared from the fat body of 0-h wandering stage larvae of Neobellieria bullata (Dipt., Sacrophagidae). Fenarimol had no influence on the formation of ecdysone, but it was an effective inhibitor of cytochrome P-450-dependent ecdysone 20-monooxygenase.

引用

页码：261 / 263

页数：3

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