ACCUMULATION OF WILD-TYPE P53 IN MENINGIOMAS

被引：35

作者：

ELLISON, DW

LUNEC, J

GALLAGHER, PJ

STEART, PV

JAROS, E

GATTER, KC

机构：

[1] SOUTHAMPTON GEN HOSP,DEPT NEUROPATHOL,SOUTHAMPTON SO9 4XY,HANTS,ENGLAND

[2] UNIV NEWCASTLE UPON TYNE,SCH MED,CANC RES UNIT,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

[3] JOHN RADCLIFFE HOSP,NUFFIELD DEPT PATHOL,OXFORD OX3 9DU,ENGLAND

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1995年 / 21卷 / 02期

关键词：

MENINGIOMA; P53; GENE; DNA REPAIR; PROLIFERATION;

D O I：

10.1111/j.1365-2990.1995.tb01040.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The p53 tumour suppressor gene contributes to the regulation of DNA repair and the initiation of apoptosis. Mutations of this gene and nuclear accumulation of its protein product are features of a large variety of tumours. A histological spectrum of meningiomas, including anaplastic examples and a meningosarcoma, was analysed for accumulation of the p53 protein and mutations in exons 4-9 of the p53 gene. No mutations were found, but 9/34 (26%) tumours showed accumulation of the p53 protein. The p53-positive meningiomas came from across the histological spectrum and were not restricted to the anaplastic group, The accumulation of wild-type p53 in a proportion of meningiomas may reflect this gene's role in DNA repair, or its enhanced stability when bound to cellular proteins such as the mdm-2 gene product.

引用

收藏

页码：136 / 142

页数：7

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