BETA-A4 AMYLOID PROTEIN AND ITS PRECURSOR IN ALZHEIMERS-DISEASE

被引：36
作者：
BUSH, AI
BEYREUTHER, K
MASTERS, CL
机构：
[1] UNIV MELBOURNE, DEPT PATHOL, PARKVILLE, VIC 3052, AUSTRALIA
[2] ROYAL PK HOSP, MENTAL HLTH RES INST VICTORIA, PARKVILLE 3052, AUSTRALIA
[3] UNIV HEIDELBERG, CTR MOLEC BIOL, W-6900 HEIDELBERG, GERMANY
来源：
PHARMACOLOGY & THERAPEUTICS | 1992年 / 56卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0163-7258(92)90039-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The betaA4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.
引用
收藏
页码：97 / 117
页数：21
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