COMPATIBILITY PROBLEMS OF CHLORPROMAZINE HCL-STEARATE LUBRICANTS EXAMINED BY DIFFERENTIAL SCANNING CALORIMETRY

被引：5
|
作者：
LIN, SY
KAO, YH
机构：
[1] Biopharmaceutics Laboratory, Department of Medical Research, Veterans General Hospital-Taipei, Shih-Pai, Taipei
来源：
JOURNAL OF THERMAL ANALYSIS | 1990年 / 36卷 / 7-8期
关键词：
D O I：
10.1007/BF01913646
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
Differential scanning calorimetry (DSC) was used to investigate the interactions between chlorpromazine HCl (CPZ) and stearate lubricants. The phase diagram was constructed for each CPZ-stearate system. An unknown endothermic peak at 145-degrees-C was found for the CPZ-stearate lubricants; this was affected by the grinding and heating processes. This unknown endothermic peak proved to relate to a polymorphism transition but was not an incompatibility problem. Three polymorphisms of CPZ were also determined by DSC analysis and IR spectrophotometry.
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页码：2493 / 2504
页数：12
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