SUPPRESSOR CALCIUM INFUSION RAISES PLASMA ATRIAL-NATRIURETIC-PEPTIDE CONCENTRATIONS IN HUMANS

被引：4

作者：

FINN, WL ^{[1
]}

TUNNY, TJ ^{[1
]}

KLEMM, SA ^{[1
]}

THOMPSON, RE ^{[1
]}

GORDON, RD ^{[1
]}

机构：

[1] UNIV QUEENSLAND, GREENSLOPES HOSP, DEPT MED, ENDOCRINE HYPERTENS RES UNIT, BRISBANE, QLD 4120, AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1990年 / 17卷 / 03期

关键词：

aldosterone; atrial natriuretic peptide; blood pressure; calcium infusion; ionized calcium; man; natriuresis; renin; total calcium;

D O I：

10.1111/j.1440-1681.1990.tb01301.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Calcium was infused in normal subjects in subpressor dosage to examine the effects of raised calcium levels on atrial natriuretic peptide (ANP) concentrations. 2. Calcium infusion progressively raised serum ionized and total calcium concentrations significantly, without raising mean arterial pressure or heart rate. 3. Plasma ANP concentrations increased significantly by 5 min of infusion and increased further by 15 min (approximately 40%) to levels which were maintained to 60 min. 4. Urinary sodium excretion increased by 140% during calcium infusion. 5. Calcium may affect secretory as well as contractile functions of the atrial myocyte. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：173 / 177

页数：5

共 21 条

[1] CALCIUM, PARATHYROID-HORMONE, AND SYMPATHOADRENAL SYSTEM [J].