[1] Univ Hosp Southampton NHS Fdn Trust, Anaesthesia & Crit Care Res Unit, Southampton, Hants, England
[2] Univ Hosp Southampton NHS Fdn Trust, NIHR Resp Biomed Res Unit, Crit Care Res Area, Southampton, Hants, England
[3] Univ Southampton, Integrat Physiol & Crit Illness Grp, Clin & Expt Sci, Fac Med, Southampton SO16 6YD, Hants, England
[4] UCL, Ctr Anaesthesia, UCLH NIHR Biomed Res Ctr, London, England
[5] Dept Anaesthesia, Ctr Block,Tremona Rd, Southampton SO16 6YD, Hants, England
[6] GICU, Mailpoint 27,Ctr Block,Tremona Rd, Southampton SO16 6YD, Hants, England
[7] UCL, 1st Floor,Suite A,Maple House, London W1T 7DN, England