INHIBITORY EFFECT OF NAD(P)H-QUINONE OXIDOREDUCTASE ON AUTOXIDATION OF 6-HYDROXYDOPA AND 6-HYDROXYDOPAMINE

被引：0

作者：

RESCIGNO, A ^{[1
]}

PORCU, MC ^{[1
]}

SANJUST, E ^{[1
]}

RINALDI, AC ^{[1
]}

RINALDI, A ^{[1
]}

机构：

[1] UNIV ROMA TOR VERGATA,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,ROME,ITALY

来源：

BIOCHEMICAL ARCHIVES | 1995年 / 11卷 / 03期

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D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

6-Hydroxydopa and 6-hydroxydopamine undergo autoxidation in the presence of molecular oxygen giving rise to the corresponding p-quinones. NAD(P)H:quinone oxidoreductase (QR) purified from Glycine max showed that it inhibited autoxidation of 6-hydroxydopa and 6-hydroxydopamine. The inhibition of autoxidation of 6-hydroxydopa was greater than B-hydroxydopamine. QR had a potentiated effect in preventing 6-hydroxydopa oxidation in the presence of catalase and superoxide dismutase. Reduced glutathione increased protective effect when incubated with QR on both 6-hydroxydopa and B-hydroxydopamine. Homogenized tissues from rat brain also showed to inhibit 6-hydroxydopa autoxidation. Our observations suggest a possible role for brain NAD(P)H:quinone oxidoreductase in protection of neurons from the toxic effect of quinones.

引用

页码：161 / 169

页数：9

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