MEASUREMENT OF DOPAMINE, HVA AND HMMA IN UNTIMED URINE SAMPLES - ESTABLISHMENT OF AGE-RELATED REFERENCE DATA IN CHILDREN

被引：18

作者：

HENDERSON, MJ ^{[1
]}

HENEY, D ^{[1
]}

MCGINLAY, JM ^{[1
]}

LEWIS, I ^{[1
]}

BAILEY, C ^{[1
]}

机构：

[1] ST JAMES UNIV HOSP,DEPT PAEDIAT,LEEDS LS9 7TF,W YORKSHIRE,ENGLAND

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 1992年 / 29卷

关键词：

CATECHOLAMINES; NEUROBLASTOMA; CAPILLARY GAS CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY;

D O I：

10.1177/000456329202900207

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We describe assays for homovanillic acid, hydroxymethylmandelic acid and dopamine that have proven practical and reliable during 3 years of routine use. Homovanillic and hydroxymethylmandelic acids were measured as trimethyl silyl derivatives by capillary gas chromatography. Dilution of samples prior to extraction was found to be necessary to achieve consistent recoveries of these acidic metabolites. Dopamine was assayed by high pressure liquid chromatography with electrochemical detection using an optimized method of catecholamine isolation that involved both ion exchange and alumina extraction. Untimed urine samples were collected from 140 hospitalized children. Age related reference data for the excretion of all three metabolites are reported. We suggest certain precautions that should be observed when using untimed samples and relating the results to creatinine excretion.

引用

页码：162 / 167

页数：6

共 20 条

[1]

ASSADI FK, 1985, J PEDIATR, V105, P562

[2]

BACHMANN KD, 1972, HDB KINDERHEIKUNDE 2, V8

[3] INTERNATIONAL CRITERIA FOR DIAGNOSIS, STAGING, AND RESPONSE TO TREATMENT IN PATIENTS WITH NEURO-BLASTOMA [J].

BRODEUR, GM ;

SEEGER, RC ;

BARRETT, A ;

BERTHOLD, F ;

CASTLEBERRY, RP ;

DANGIO, G ;

DEBERNARDI, B ;

EVANS, AE ;

FAVROT, M ;

FREEMAN, AI ;

HAASE, G ;

HARTMANN, O ;

HAYES, FA ;

HELSON, L ;

KEMSHEAD, J ;

LAMPERT, F ;

NINANE, J ;

OHKAWA, H ;

PHILIP, T ;

PINKERTON, CR ;

PRITCHARD, J ;

SAWADA, T ;

SIEGEL, S ;

SMITH, EI ;

TSUCHIDA, Y ;

VOUTE, PA .

JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (12) :1874-1881

[4] A SIMPLE, OPTIMIZED AND RAPID ASSAY FOR URINARY FREE CATECHOLAMINES BY HPLC WITH ELECTROCHEMICAL DETECTION [J].

DAVIDSON, DF ;

FITZPATRICK, J .

ANNALS OF CLINICAL BIOCHEMISTRY, 1985, 22 (MAY) :297-303

[5] SCREENING FOR NEURO-BLASTOMA - JAPANESE STUDIES SUGGEST THAT IT MAY SAVE LIVES [J].

DRAPER, GJ .

BRITISH MEDICAL JOURNAL, 1988, 297 (6642) :152-153

[6] DICARBOXYLIC ACIDURIA AND MEDIUM CHAIN TRIGLYCERIDE SUPPLEMENTED MILK [J].

HENDERSON, MJ ;

DEAR, PRF .

ARCHIVES OF DISEASE IN CHILDHOOD, 1986, 61 (06) :610-611

[7]

JACOBSEN FK, 1980, LANCET, V1, P319

[8]

KELLIE SJ, 1986, AUST PAEDIATR J, V22, P313

[9] CATECHOLAMINE METABOLISM IN NEUROBLASTOMA [J].

LABROSSE, EH ;

COMOY, E ;

BOHUON, C ;

ZUCKER, JM ;

SCHWEISGUTH, O .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1976, 57 (03) :633-638

[10] DETERMINATION OF URINARY 3-METHOXY-4-HYDROXYMANDELIC AND 3-METHOXY-4-HYDROXYPHENYLACETIC ACIDS BY FUSED-SILICA CAPILLARY GAS-CHROMATOGRAPHY [J].

PRICE, S ;

DAVENPORT, K ;

BERG, JD .

ANNALS OF CLINICAL BIOCHEMISTRY, 1986, 23 :351-353

← 1 2 →