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EFFECT OF ASPARTAME ON N-METHYL-D-ASPARTATE-SENSITIVE L-[H-3]GLUTAMATE BINDING-SITES IN RAT-BRAIN SYNAPTIC-MEMBRANES
被引：21
|作者：
PANHOU, H
SUDA, Y
OHE, Y
SUMI, M
YOSHIOKA, M
机构：
[1] Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Nagaotoge-cho
关键词：
Aspartame;
Competitive inhibition;
Glutamate binding;
N-Methyl-d-aspartate-sensitive receptor;
Neurotoxicity of sweetener;
D O I：
10.1016/0006-8993(90)91729-Z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Aspartame (l-aspartyl-l-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit l-[3H]glutamate binding to its N-methyl-d-aspartate-specific receptors. l-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while the other metabolites, l-phenylalanine and methanol, had no effect at the same concentration. Aspartame caused a significant change in the affinities of l-[3H]glutamate binding without altering the Vmax values of the binding, suggesting the inhibition is competitive. These in vitro findings suggested that aspartame may act directly on the N-methyl-d-aspartate-sensitive glutamate recognition sites in the brain synaptic membranes. © 1990.
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页码：351 / 353
页数：3
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