Diabetic Ketoacidosis due to Simultaneous Acute-onset Type 1 Diabetes and Graves' Disease

被引：0

作者：

Kobashi, Chikaaki ^{[1
]}

Muranaka, Emiri ^{[1
]}

Motoyoshi, Kanako ^{[1
]}

Satou, Yukihiro ^{[1
]}

Ikeda, Tadashi ^{[2
]}

Shigeta, Kouichi ^{[1
]}

Urakaze, Masaharu ^{[1
]}

机构：

[1] Kamiichi Gen Hosp, Med & Diabet Ctr, Toyama, Japan

[2] Ikeda Clin, Toyama, Japan

来源：

JOURNAL OF DIABETES & METABOLISM | 2016年 / 7卷 / 05期

关键词：

Diabetic ketoacidosis; Type; 1; diabetes; Graves' disease; Autoimmune polyglandular syndrome; Human leukocyte antigen;

D O I：

10.4172/2155-6156.1000671

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An 18-year old Japanese woman with thirst, weight loss and palpitations for a few weeks' duration was admitted. Her diagnosis was diabetic ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves' disease (GD) (autoimmune polyglandular syndrome type 3 variant; APS3v). She was treated with intensification therapy with insulin and anti-thyroid drugs. Human leukocyte antigen testing revealed that her HLA type was HLA- DRB1*08:02-DQA1*03:01-DQB1*03:02 haplotype, which was vulnerable not only to APS3v, but also to both acute-onset T1D and GD. This genetic factor probably contributes to the simultaneous occurrence of T1D and GD.

引用

页数：2

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