THERAPY OF CHRONIC HEPATITIS-B WITH RECOMBINANT HUMAN ALPHA-INTERFERON AND GAMMA-INTERFERON

被引：50
|
作者：
DIBISCEGLIE, AM
RUSTGI, VK
KASSIANIDES, C
LISKERMELMAN, M
PARK, Y
WAGGONER, JG
HOOFNAGLE, JH
机构：
[1] Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
来源：
HEPATOLOGY | 1990年 / 11卷 / 02期
关键词：
D O I：
10.1002/hep.1840110217
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Eight patients with chronic hepatitis B entered a pilot study of gamma interferon and alpha interferon in combination. Gamma interferon alone had minimal inhibitory effects on serum levels of hepatitis B virus as monitored by serum HBV DNA and DNA‐polymerase activity. The drug also gave troublesome side effects. In contrast, alpha interferon had more potent inhibitory effects on serum HBV levels and fewer side effects. When combined, the two interferons showed no additive or synergistic effects in inhibiting serum levels of HBV DNA or DNA polymerase. These findings indicate that the addition of gamma interferon to alpha interferon provides no additional antiviral effects but contributes significantly to side effects. Copyright © 1990 American Association for the Study of Liver Diseases
引用
收藏
页码：266 / 270
页数：5
相关论文
共 50 条
  • [1] COMBINED RECOMBINANT ALPHA-INTERFERON AND GAMMA-INTERFERON THERAPY OF CHRONIC HEPATITIS-B
    CARRENO, V
    LABANDA, F
    MORA, I
    GOMEZ, C
    BARTOLOME, J
    QUIROGA, JA
    GUTIEZ, J
    CASTILLO, I
    BAS, C
    IBARRA, MZ
    PORRES, JC
    HEPATOLOGY, 1987, 7 (05) : 1117 - 1117
  • [2] TREATMENT OF CHRONIC HEPATITIS-B IN CHILDREN WITH RECOMBINANT ALPHA-INTERFERON AND GAMMA-INTERFERON
    MORENO, MR
    GUARDIA, L
    PORRES, JC
    RUA, MJ
    BARTOLOME, J
    CARRENO, V
    HEPATOLOGY, 1990, 12 (04) : 848 - 848
  • [3] STUDIES ON INDUCTION OF ALPHA-INTERFERON AND GAMMA-INTERFERON IN CHRONIC HEPATITIS-B PATIENTS
    YAO, GB
    ZHANG, LM
    WEN, YM
    LOU, HZ
    YANG, JQ
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1985, 15 (04): : 562 - 562
  • [4] TREATMENT WITH HUMAN GAMMA-INTERFERON OF CHRONIC HEPATITIS-B - COMPARATIVE-STUDY WITH ALPHA-INTERFERON
    KAKUMU, S
    ISHIKAWA, T
    MIZOKAMI, M
    ORIDO, E
    YOSHIOKA, K
    WAKITA, T
    YAMAMOTO, M
    JOURNAL OF MEDICAL VIROLOGY, 1991, 35 (01) : 32 - 37
  • [5] A RANDOMIZED, CONTROLLED TRIAL OF RECOMBINANT ALPHA-INTERFERON THERAPY FOR CHRONIC HEPATITIS-B
    DIBISCEGLIE, AM
    BERGASA, NV
    FONG, TL
    FRIED, MW
    SWAIN, M
    BAKER, B
    KORENMAN, J
    WAGGONER, JG
    PARK, Y
    HOOFNAGLE, JH
    HEPATOLOGY, 1991, 14 (04) : A70 - A70
  • [6] A RANDOMIZED, CONTROLLED TRIAL OF RECOMBINANT ALPHA-INTERFERON THERAPY FOR CHRONIC HEPATITIS-B
    DIBISCEGLIE, AM
    FONG, TL
    FRIED, MW
    SWAIN, MG
    BAKER, B
    KORENMAN, J
    BERGASA, NV
    WAGGONER, JG
    PARK, Y
    HOOFNAGLE, JH
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 1993, 88 (11): : 1887 - 1892
  • [7] TREATMENT OF CHRONIC TYPE-B HEPATITIS WITH RECOMBINANT HUMAN ALPHA-INTERFERON AND GAMMA-INTERFERON IN COMBINATION - A DOSE-FINDING STUDY
    DIBISCEGLIE, AM
    KASSIANIDES, C
    LISKERMELMAN, M
    RUSTGI, V
    MURRAY, L
    PARK, Y
    WAGGONER, JG
    HOOFNAGLE, JH
    HEPATOLOGY, 1987, 7 (05) : 1116 - 1116
  • [8] AUTOANTIBODIES DURING ALPHA-INTERFERON THERAPY FOR CHRONIC HEPATITIS-B
    FATTOVICH, G
    BETTERLE, C
    BROLLO, L
    PEDINI, B
    GIUSTINA, G
    REALDI, G
    ALBERTI, A
    RUOL, A
    JOURNAL OF MEDICAL VIROLOGY, 1991, 34 (02) : 132 - 135
  • [9] IS THERE AN ALTERNATIVE TO ALPHA-INTERFERON IN CHRONIC HEPATITIS-B
    DEMOURA, MC
    VELOSA, J
    PINTO, HC
    JOURNAL OF HEPATOLOGY, 1991, 13 : S12 - S16
  • [10] PROLONGED RECOMBINANT LEUKOCYTE ALPHA-INTERFERON TREATMENT OF CHRONIC HEPATITIS-B
    DUSHEIKO, GM
    DIBISCEGLIE, A
    BOWYER, S
    SACKS, E
    KEW, MC
    HEPATOLOGY, 1984, 4 (04) : 789 - 789
12345