Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA

被引：17

作者：

Arima, Hidetoshi ^{[1
]}

Motoyama, Keiichi ^{[1
]}

Higashi, Taishi ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, 5-1 Oe Honmachi, Kumamoto 8620973, Japan

来源：

PHARMACEUTICALS | 2012年 / 5卷 / 01期

基金：

日本学术振兴会;

关键词：

cyclodextrin; polyamidoamine dendrimer; conjugate; siRNA delivery; multifunction;

D O I：

10.3390/ph5010061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with beta-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system.

引用

页码：61 / 78

页数：18

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