THE REGION OF COMMON ALLELIC LOSSES IN SPORADIC RENAL-CELL CARCINOMA IS BORDERED BY THE LOCI-D3S2 AND THRB

被引：46
作者：
VANDERHOUT, AH [1 ]
VANDERVLIES, P [1 ]
WIJMENGA, C [1 ]
LI, FP [1 ]
OOSTERHUIS, JW [1 ]
BUYS, CHCM [1 ]
机构：
[1] NCI,BOSTON,MA
来源：
GENOMICS | 1991年 / 11卷 / 03期
关键词：
D O I：
10.1016/0888-7543(91)90060-R
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cytogenetic studies and DNA analysis have shown that the short arm of chromosome 3 is the region in the genome that is commonly deleted in renal cell carcinoma. By studying loss of heterozygosity in 41 matched tumor/normal kidney tissue pairs, we could delimit the commonly deleted part of 3p to the region between the loci THRB (in 3p24) and D3S2 (in 3p21). The regions on 3p suggested to be involved in the Von Hippel-Lindau syndrome and in hereditary renal cell carcinoma are both outside this smallest region of overlapping deletions. Consequently, renal cell cancer would be an illustration of the possibility that different genes cause the same type of tumor. © 1991.
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页码：537 / 542
页数：6
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